[x_IS0YUM]

mine would probably be...

Yume Tsukai
Welcome to the NHK
Air
Sola
xxHolic
and Clannad.

they're all pretty good :]

[DOVAHKIIN]

Well, I know which series had a terrible rather FAMILIAR plot..

*COUGH* Gundam Seed Destiny.

[srenity]

i always thought yume tsukai was just like any other magical-girl type anime, except with a different theme.

School Days definately has my vote for interesting and unusual.

[Clix]

Haha, Welcome to the NHK. That was such an odd anime.

Moetan is quite the odd plot.

[blitzbeat2]

yes please school days has the weirdest plot it became to love story to a total psychotic story

[smirk_it]

I would say melancholy of haruhi suzumiya

[superfreakk]

Well, I know which series had a terrible rather FAMILIAR plot..

*COUGH* Gundam Seed Destiny.

lol, agreed.

And for me, it's xxxHolic, The Melancholy of Haruhi Suzumiya, School Days, and Death Note (well, the manga at least, I don't know about the anime). I also thought Revolutionary Girl Utena was pretty interesting.

[blurr]

Sayonara Zetsubou Sensei <- definitely the weirdest out of all the ones i`ve seen xP.

School Days - err.. started out pretty generic & i think the person just wanted to end it quick so he killed everyone =_=? but wouldn't call it the weirdest - i`ve seen a lot of anime like this actually ._."

Ouran High School Host Club <- different plot to most anime i think; if not simply entertaining.

[MoonlightConfessionx3]

^ yeah. Ouran High School Host Club had a pretty interesting/strange plot. It was still entertaining though.

[BishieAddict]

the serial experiments of Lain is the weirdest anime I've seen. the ending was highly unexpected.

[lee-chan]

I have a few ones I think are interesting:

Spirited Away - not your typical anime, its gorgeous and love the plot
Howl's Moving Castle - love everything about it
X/1999- despite the violence it was different

[x_IS0YUM]

^ oh yeah. i think anything by Miyazaki is really..
wow.

[Jang_Yoon_Jung ^ ^]

Ouran High School Host Club - I loved this one, and I never heard of a host club so I thought it was pretty interesting. xD

Death Note - This one's very interesting. O__O;; Instead of the main character being a hero, he's a killer...( though he doesn't think of himself that way... )

Wallflower - I thought this one was interesting. xD;;; sumiko's funny, with all her horror stuff >.>;

Pucca - I guess Pucca counts as anime, right? right? xD This one's interesting to me...with all the kissy stuff going on between Pucca and Garu xD

Yoh Oo Bi - It' a Korean anime movie...I don't know if many people heard about it, but it's very interesting...kind of reminded me of Miyazaki's movies. xD

Spirited Away - Definently unique and interesting <3

Azumanga Daioh - funny and interesting. At least to me. xD

Lovely Complex - the most interesting romantic manga I have ever read xD

[Take Five]

probably mind game, even if it is a movie. you can't beat getting stuck inside a whale while trying to escape the yakuza.

[Mirae-chan]

Sayonara Zetsubou Sensei <3 absolutely nuts, I love how each of the students has their own weirdo personality/quirks

[tranceeee]

definitely ouran host club~ oh and hana kimi has a pretty interesting plot to it =D

[Special Ed]

Probably for me would be:

Death Note (omfg the potato chip scene was amazing! I am still amazed even after a year later. how the hell do they come up with those stuff?!)

The Melancholy of Haruhi Suzumiya (words can't even begin to describe this anime)

Fooly Cooly (I've watched this like 3 times and still don't get it)

Sayonara Zetsubou Sensei (dark humor I suppose ...)

When They Cry (Ummm ...)

[x SaRaNg HaE x]

Death Note and Elfen Lied.

Most twisted plots ever.

[MUGETSU]

the serial experiments of Lain is the weirdest anime I've seen. the ending was highly unexpected.

I agree.

one of the animes where you actually need to have a brain to understand it. haha

[summerdamsel]

death note
yeah.. it was definitely interesting
blood+
looool i just love these type of stories.. when they include science and stuff..
futari ecchi
more of unusual XDDDD